The liver is one of the most complicated organs in the body and plays a huge role in handling sugars. When should you take metformin to work with the liver? Metformin is an oral antidiabetic drug for the treatment of diabetes. Learn how it works to lower blood sugar, its benefits, side effects & use for weight loss. Metformin is a type of oral medication used to treat type 2 diabetes — and according to Gary Scheiner, CDE, in his book, “Until There is a Cure,” metformin is. Type 2 diabetes is caused by a lack of glycogen storage capacity resulting from insulin resistance and excessive glucagon mediated hepatic gluconeogenesis. Diabetes . What do you know about this unsung hero among diabetes drugs? Check out this “biography” of metformin to learn everything you ever wanted to know, but were afraid. Metformin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes..